Elevated circulating and placental SPINT2 is associated with placental dysfunction

CN Murphy; SP Walker; TM Macdonald; E Keenan; NJ Hannan; ME Wlodek; J Myers; JF Briffa; T Romano; A Roddy Mitchell; CA Whigham; P Cannon; TV Nguyen; M Kandel; N Pritchard; S Tong; TJ Kaitu’u-lino

Journal article

Elevated circulating and placental SPINT2 is associated with placental dysfunction

CN Murphy, SP Walker, TM Macdonald, E Keenan, NJ Hannan, ME Wlodek, J Myers, JF Briffa, T Romano, A Roddy Mitchell, CA Whigham, P Cannon, TV Nguyen, M Kandel, N Pritchard, S Tong, TJ Kaitu’u-lino

International Journal of Molecular Sciences | MDPI | Published : 2021

DOI: 10.3390/ijms22147467

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Abstract

Biomarkers for placental dysfunction are currently lacking. We recently identified SPINT1 as a novel biomarker; SPINT2 is a functionally related placental protease inhibitor. This study aimed to characterise SPINT2 expression in placental insufficiency. Circulating SPINT2 was assessed in three prospective cohorts, collected at the following: (1) term delivery (n = 227), (2) 36 weeks (n = 364), and (3) 24–34 weeks’ (n = 294) gestation. SPINT2 was also measured in the plasma and placentas of women with established placental disease at preterm (<34 weeks) delivery. Using first-tri-mester human trophoblast stem cells, SPINT2 expression was assessed in hypoxia/normoxia (1% vs. 8% O2), and followi..

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University of Melbourne Researchers

Susan Walker Author

Teresa MacDonald Author

Emerson Keenan Author

Natalie Hannan Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Funding for this work was provided by the National Health and Medical Research Council (#1065854, #1183854, #116071, #2000732), National Health and Medical Research Council Fellowships to TKL (#1159261), NJH (#1146128), ST (#1136418). The funders played no role in study design or analysis.